Medications to Maintain Cardiac Output and for Postresuscitation Stabilization

Medication Dose Range Comment
Inamrinone 0.75–1 mg/kg IV/IO over 5 minutes; may repeat × 2 then: 5–10 mcg/kg per minute Inodilator
Dobutamine 2–20 mcg/kg per minute IV/IO Inotrope; vasodilator
Dopamine 2–20 mcg/kg per minute IV/IO Inotrope; chronotrope; renal and splanchnic vasodilator in low doses; pressor in high doses
Epinephrine 0.1–1 mcg/kg per minute IV/IO Inotrope; chronotrope; vasodilator in low doses; pressor in higher doses
Milrinone Loading dose: 50 mcg/kg IV/IO over 10–60 min then 0.25–0.75 mcg/kg per minute Inodilator
Norepinephrine 0.1–2 mcg/kg per minute Vasopressor
Sodium nitroprusside Initial: 0.5–1 mcg/kg per minute; titrate to effect up to 8 mcg/kg per minute Vasodilator Prepare only in D5W
  • IV indicates intravenous; and IO, intraosseous.

  • Alternative formula for verifying dose during continuous infusion:

  • Infusion rate
    This graphic shows the alternative formula for verifying dose during continuous infusion. The formula is as follows: Infusion rate, expressed in milliliters per hour, is equal to [weight in kilograms times the dose, stated in micrograms per kilogram per minute, times 60, the number of minutes per hour] divided by the concentration, expressed in micrograms per milliliter.